Pravastatin, A 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion

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• 作者：Joyce ; Myles ; Kelly ; Cathal ; Winter ; Des ; Chen ; Gang ; Leahy ; Austin ; Bouchier-Hayes ; David
• 刊名：Journal of Surgical Research
• 出版年：2001
• 出版时间：November, 2001
• 年：2001
• 卷：101
• 期：1
• 页码：79-84
• 全文大小：275 K

文摘

Background. Renal dysfunction due to ischemia-reperfusion (IR) injury is a common problem following renovascular surgery or kidney transplantation. There is a lot of emerging evidence that statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, have anti-inflammatory properties and exert direct beneficial effects on the vascular endothelium. The aim of this study was to determine if pretreatment with pravastatin would attenuate the acute renal dysfunction that occurs following IR injury in an experimental model.