Hydrogen sulfide inhibits giant depolarizing potentials and abolishes epileptiform activity of neonatal rat hippocampal slices

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• 作者：Aleksey V. Yakovlev^a ; ^{alv.yakovlev@gmail.com} ; Evgeniya D. Kurmasheva^a ; ^{harlequin18@gmail.com} ; Rashid Giniatullin^b ; ^{rashid.giniatullin@uef.fi} ; Ilgam Khalilov^a ; ^c ; ^d ; ^{ilgam.khalilov@inserm.fr} ; Guzel F. Sitdikova^a ; ^{guzel.sitdikova@kpfu.ru}
• 关键词：3-MST ; 3-mercaptopyruvate sulfurtransferase ; ACSF ; artificial cerebrospinal fluid ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; CAT ; cysteine aminotransferase ; CBS ; cystathionine beta-synthase ; CNQX ; 6-cyano-7-nitroquinoxaline-2 ; 3dione ; CSE ; cystathionine gamma-lyase ; DAO ; d-amino acid oxidase ; d-APV ; d-2-amino-5-phosphopentanoate ; EGTA ; ethylene glycol-bis(2-aminoethylether)-N ; N ; N&prime ; N&prime ; -tetraacetic acid ; GABA ; γ-aminobutyric acid ; GDPs ; giant depolarizing potentials ; H2
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：153-165
• 全文大小：716 K
• 卷排序：340

文摘

Exogenous and endogenous H2S decreases network activity in the immature rat hippocampus. H2S evokes TTX-resistant depolarizations of neurons and reduces outward K+ currents. H2S decreases NMDA-mediated currents without effects on GABAA and AMPA/kainate responses. H2S completely abolishes bicuculline-evoked epileptiform activity in the hippocampus of neonatal rats.