CB₁ cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABA_A receptor blockade in the dorsomedial division of the ventromedial hypothalamus

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• 作者：Tayllon dos Anjos-Garcia^a ; Farhad Ullah^a ; Luiz Luciano Falconi-Sobrinho^a ; Norberto Cysne Coimbra^a ; ^b ; ^{nccoimbr@fmrp.usp.br}
• 关键词：Endocannabinoid neuromodulators ; GABAA receptor ; Ventromedial hypothalamus ; Defensive behaviour ; CB1 cannabinoid receptor ; TRPV1 channel
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：156-166
• 全文大小：2669 K
• 卷排序：113

文摘

Administration of bicuculline intra-VMHdm induced panic-like responses. Anandamide attenuated defence responses induced by bicuculline. Anandamide modulates the pro-aversive effects of bicuculline, recruiting CB1 receptors. AM251 potentiated the non-oriented escape induced by bicuculline. AM251-induced potentiation of bicuculline effect is related to TRPV1 vanilloid receptor activity.