Effects of ZD7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on term-pregnant rat uterine contractility in vitro

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Effects of ZD7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on term-pregnant rat uterine contractility in vitro

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作者：Mohammed Alotaibi^a ; ^{mfalotaibi@ksu.edu.sa} ; Karima Kahlat^b ; Taoufik Nedjadi^c ; Laiche Djouhri^a
关键词：Uterus ; HCN channels ; Contraction ; ZD7288 ; Smooth muscle
刊名：Theriogenology
出版年：2017
出版时间：1 March 2017
年：2017
卷：90
期：Complete
页码：141-146
全文大小：1061 K
卷排序：90

文摘

Pregnant uterine contractility is modulated by HCN channels. Blocking HCN channels with ZD7288 decreases or inhibits the uterine activity. The mechanism relies on preventing calcium entry into the myometrial cells.