A green approach for highly regioselective syntheses of furo[3,2-h]quinolines in aqueous medium

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• 作者：Swarbhanu Sarkar^a ; Rammyani Pal^a ; Nivedita Chatterjee^a ; Samrat Dutta^a ; Subhendu Naskar^b ; Asish Kumar Sen^a ; ^{asishksen@yahoo.com} ; ^{aksen@iicb.res.in}
• 关键词：Furo[3 ; 2-h]quinolines ; Micelle ; Reaction in water ; Cu-free Sonogashira ; 5-exo-Dig cyclization ; One-pot
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：17 July, 2013
• 年：2013
• 卷：54
• 期：29
• 页码：3805-3809
• 全文大小：899 K

文摘

An environmentally benign, high yielding, and operationally simple protocol has been developed for the regioselective synthesis of furo[3,2-h]quinolines in aqueous micellar medium involving Cu-free domino Sonogashira reaction followed by 5-endo-dig-cyclization of substituted 8-hydroxyquinolines and terminal alkyne by using Pd(C₆H₅CN)Cl₂ as catalyst and 2-pyridinecarboxaldehyde methylphenyl hydrazone as ligand under aerobic condition.