Minocycline prevents cerebral malaria, confers neuroprotection and increases survivability of mice during Plasmodium berghei ANKA infection

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• 作者：Thittayil Suresh Apoorv ; Phanithi Prakash Babu ; ^{prakashbabuphanithi@gmail.com} ; ^{prakash@uohyd.ac.in}
• 关键词：CM ; cerebral malaria ; ECM ; experimental cerebral malaria ; CXCL10 ; C-X-C-motif ligand 10 ; CCL5 ; C-C motif ligand 5 ; CCL2 ; C-C motif ligand 2 ; CXCR3 ; C-X-C-motif receptor 3 ; CCR2 ; C-C chemokine receptor type 2
• 刊名：Cytokine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：113-123
• 全文大小：2717 K
• 卷排序：90

文摘

First study showing the effect of minocycline on cerebral malaria outcome. Prevention of hemorrhages and neurodegeneration in memory-associated hippocampus. Inflammatory mediators are reduced irrespective of parasite load. Possible adjunctive therapy for conferring neuroprotection.