A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures

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• 作者：Anita R. Iskandar^a ; ¹ ; ^{Anita.Iskandar@pmi.com} ; Carole Mathis^a ; ¹ ; ^{Carole.Mathis@pmi.com} ; Walter K. Schlage^b ; ^{WK.Schlage@t-online.de} ; Stefan Frentzel^a ; ^{Stefan.Frentzel@pmi.com} ; Patrice Leroy^a ; ^{Patrice.Leroy@pmi.com} ; Yang Xiang^a ; ^{Yang.Xiang@pmi.com} ; Alain Sewer^a ; ^{Alain.Sewer@pmi.com} ; Shoaib Majeed^a ; ^{Shoaib.Majeed@pmi.com} ; Laura Ortega-Torres^a ; ^{Laura.OrtegaTorres@pmi.com} ; Stephanie Johne^a ; ^{Stephanie.Johne@pmi.com} ; Emmanuel Guedj^a ; ^{Emmanuel.Guedj@pmi.com} ; Keyur Trivedi^a ; ^{Keyur.Trivedi@pmi.com} ; Gilles Kratzer^a ; ^{Gilles.Kratzer@gmail.com} ; Celine Merg^a ; ^{Celine.Merg@pmi.com} ; Ashraf Elamin^a ; ^{Ashraf.Elamin@pmi.com} ; Florian Martin^a ; ^{Florian.Martin@pmi.com} ; Nikolai V. Ivanov^a ; ^{Nikolai.Ivanov@pmi.com} ; Manuel C. Peitsch^a ; ^{Manuel.Peitsch@pmi.com} ; Julia Hoeng^a ; ^{Julia.Hoeng@pmi.com}
• 关键词：3D ; Three-dimensional ; AK ; Adenylate kinase ; BIF ; Biological impact factor ; CBF ; Ciliary beating frequency ; CCL ; Chemokine (C-C motif) ligand ; CFA ; Cell fate ; CPR ; Cell proliferation ; CS ; Cigarette smoke ; CST ; Cell stress ; CXCL ; Chemokine (C-X-C motif) ligand ; DEG ; Differentially expressed gene ; EGF ; Epidermal growth factor ; FDR ; False discovery rate ; FFT ; Fast Fourier transformation ; H&E ; Hematoxylin and eosin ; IL ; Interleukin ; IPN ; Inflammatory process networks ; MiRNA ; microRNA ; MMP ; Matrix me
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：29-51
• 全文大小：4500 K
• 卷排序：39

文摘

A systems toxicology approach was applied to comprehensively assess the biological impact of a heated tobacco aerosol and cigarette smoke Series of experimental repetitions were conducted to increase robustness of the assessment Heated tobacco aerosol elicited less biological impact than cigarette smoke at similar nicotine concentration(s)