Dose-dense adjuvant chemotherapy in premenopausal breast cancer patients: A pooled analysis of the MIG1 and GIM2 phase III studies

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• 作者：Matteo Lambertini^a ; ^b ; ^{matteo.lambertini85@gmail.com} ; Marcello Ceppi^c ; ^{marcello.ceppi@hsanmartino.it} ; Francesco Cognetti^d ; ^{cognetti@ifo.it} ; Giovanna Cavazzini^e ; ^{mariagiovanna.cavazzini@aopoma.it} ; Michele De Laurentiis^f ; ^{delauren@unina.it} ; Sabino De Placido^g ; ^{deplacid@unina.it} ; Andrea Michelotti^h ; ^{a.michelotti@ao-pisa.toscana.it} ; Giancarlo Bisagniⁱ ; ^{bisagni.giancarlo@asmn.re.it} ; Antonio Durando^j ; ^{andurando63@gmail.com} ; Enrichetta Valle^k ; ^{enrichettavalle@asl8cagliari.it} ; Tiziana Scotto^l ; ^{scotto.tiziana@libero.it} ; Andrea De Censi^m ; ^{andrea.decensi@galliera.it} ; Anna Turlettiⁿ ; ^{annaturletti@virgilio.it} ; Marco Benasso^o ; ^{m.benasso@asl2.liguria.it} ; Sandro Barni^p ; ^{sandro.barni@ospedale.treviglio.bg.it} ; Filippo Montemurro^q ; ^{filippo.montemurro@ircc.it} ; Fabio Puglisi^r ; ^{fabio.puglisi@uniud.it} ; Alessia Levaggi^s ; ^{alessia.levaggi@hsanmartino.it} ; Sara Giraudi^s ; ^{sara.giraudi@hsanmartino.it} ; Claudia Bighin^a ; ^{claudia.bighin@hsanmartino.it} ; Paolo Bruzzi^c ; ^{paolo.bruzzi@hsanmartino.it} ; Lucia Del Mastro^s ; ^{lucia.delmastro@hsanmartino.it} ; for the MIG ; GIM study groups¹
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：34-42
• 全文大小：986 K
• 卷排序：71

文摘

No evidence exists to recommend a specific chemotherapy regimen in young breast cancer patients. In premenopausal women, chemotherapy can cause treatment-induced amenorrhoea and infertility. We evaluated efficacy of dose-dense chemotherapy and risk of amenorrhoea in premenopausal women. Dose-dense chemotherapy significantly improves survival in high-risk breast cancer patients. Dose-dense chemotherapy is not associated with increased risk of treatment-induced amenorrhoea.