Benzimidazole-core as an antimycobacterial agent

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• 作者：Rangappa S. Kerip> ; p>p>keriphd@gmail.com" class="auth_mail" title="E-mail the corresponding authorp>p> ; p>p>sk.rangappa@jainuniversity.ac.in" class="auth_mail" title="E-mail the corresponding authorp>p> ; p>p>kerichem@rediffmail.com" class="auth_mail" title="E-mail the corresponding authorp> ; Chethana Kolambae Rajappa ; Siddappa A. Patil ; Bhari Mallanna Nagaraja
• 关键词：AIDS ; acquired immunodeficiency syndrome ; DNA ; deoxyribonucleic acid ; EMB ; ethambuthol ; GI ; growth inhibition ; HIV ; human immunodeficiency virus ; HTS ; high throughput screening ; INH ; isoniazid ; LTBI ; latent tuberculosis infection ; MABA ; micro plate alamar blue assay ; M. africanum ; mycobacterium africanum ; M. bovis ; mycobacterium bovis ; M. caprae ; mycobacterium caprae ; MDR ; multidrug-resistant ; MIC ; minimal inhibitory concentration ; Mtb ; mycobacterium tuberculosis ; NR-Mtb ; non-replicating Mycobac
• 刊名：Pharmacological Reports
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：68
• 期：6
• 页码：1254-1265
• 全文大小：3046 K

文摘

<dl class="listitem" id="list_lis0005"><dt class="label">•dt><dd><p id="par0005">Benzimidazole core is an attractive target for drug development.p>dd><dt class="label">•dt><dd><p id="par0010">In this review we discussed benzimidazole as antitubercular agent.p>dd><dt class="label">•dt><dd><p id="par0015">Review analyzes structural requirements of benzimidazole as anti-TB agents, with SAR study.p>dd><dt class="label">•dt><dd><p id="par0020">Review will be helpful for new thoughts in the quest for rational designs anti-TB drugs.p>dd>dl>