m>chm>LPG2-dsRNA structures reveal RIG-I like end binding, but overhangs are possible

m>chm>MDA5-dsRNA complex structures show head-to-head packing on short dsRNAs

LGP2 also has MDA5-like behavior, coating dsRNA but with less cooperativity

Both human and chicken LGP2 enhance MDA5 signaling in an RNA-dependent manner