An efficient method for the synthesis of α-arylated nitroalkanes and α-arylated hydroximoyl chlorides mediated by AlCl₃

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• 作者：Zhijay Tu ; B. Rama Raju ; Tzuo-Rung Liou ; Veerababurao Kavala ; Chun-Wei Kuo ; Yaochung Jang ; Yu-Hsuan Shih ; Chun-Chao Wang ; Ching-Fa Yao
• 刊名：Tetrahedron
• 出版年：2009
• 出版时间：21 March 2009
• 年：2009
• 卷：65
• 期：12
• 页码：2436-2442
• 全文大小：916 K

文摘

Friedel–Crafts alkylation of various arenes/heteroarenes to β-nitrostyrenes mediated by aluminum chloride is described. The interesting feature of this methodology pertain the formation of different products by tuning the reaction temperature. α-Arylated nitroalkanes were formed predominately at −78 °C, whereas α-arylated hydroximoyl chlorides were obtained at room temperature without any side products in high yields.