A pharmacokinetic analysis and dietary information are necessary to confirm or reject the hypothesis on persistent organic pollutants causing type 2 diabetes

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A pharmacokinetic analysis and dietary information are necessary to confirm or reject the hypothesis on persistent organic pollutants causing type 2 diabetes

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作者：Jouko Tuomisto^a ; ^{jouko.tuomisto@thl.fi" class="auth_mail" title="E-mail the corresponding author} ; ^{j.tuomisto@dnainternet.net" class="auth_mail" title="E-mail the corresponding author} ; Riikka Airaksinen^a ; Hannu Kiviranta^a ; Erkki Tukiainen^b ; Juha Pekkanen^a ; ^c ; Jouni T. Tuomisto^a
关键词：BMI ; body mass index ; CDD ; chlorinated dibenzo-p-dioxin ; CDF ; chlorinated dibenzofuran ; DDE ; dichlorodiphenyldichloroethylene ; DDT ; dichlorodiphenyltrichloroethane ; Hp ; hepta ; Hx ; hexa ; O ; octa ; PCBs ; polychlorinated biphenyls ; PCDD/Fs ; polychlorinated dibenzo-p-dioxins and dibenzofurans ; Pe ; penta ; POP ; persistent organic pollutants ; T ; tetra ; TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzo-p-dioxin ; TEF ; toxic equivalency factor ; WHO ; World Health Organization ; WHO-TEQ ; toxic equivalencies according to WHO
刊名：Toxicology Letters
出版年：2016
出版时间：2 November 2016
年：2016
卷：261
期：Complete
页码：41-48
全文大小：739 K

文摘

•: Dioxins with long half-lives accumulate throughout the entire lifetime.
•: Pharmacokinetic models predict the measured concentrations in populations.
•: Dioxin concentrations in the body are predicted by age, animal source food and BMI.
•: Dioxins may confound the role of ample animal source food in causing diseases.
•: Diet and kinetics are vital in claiming causal roles of persistent pollutants in diseases.