Inhibiting medial septal cholinergic neurons with DREADD alleviated anxiety-like behaviors in mice

详细信息    查看全文

• 作者：Yu Zhang^a ; Ying-Ying Jiang^a ; Shan Shao^a ; Chan Zhang^a ; Feng-Yu Liu^a ; You Wan^a ; ^b ; ^c ; Ming Yi^a ; ^{mingyi@bjmu.edu.cn}
• 关键词：ChAT ; choline acetyltransferase ; CNO ; clozapine N-oxide ; DREADD ; designer receptors exclusively activated by designer drugs ; EPM ; elevated plus-maze ; MB ; marble burying ; MS ; medial septum ; NSF ; novelty-suppressed feeding ; OF ; open field ; PFA ; paraformaldehyde ; PV ; parvalbumin ; SAP ; 192 IgG-saporin
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：638
• 期：Complete
• 页码：139-144
• 全文大小：863 K
• 卷排序：638

文摘

We investigated the role of medial septal cholinergic neurons in anxiety-like behaviors with DREADD. Temporal inhibition of medial septal cholinergic neurons produced consistent anxiolytic effects in three behavioral models. Temporal inhibition of medial septal cholinergic neurons increased voluntary exploration in the open field test. These results reconciled conflicting findings from previous studies using irreversible lesions or non-specific inhibition.