Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

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Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

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作者：Saoussen Ben Halima¹ ; ² ; ³ ; Sabyashachi Mishra⁴ ; ¹² ; K. Muruga Poopathi Raja⁵ ; Michael Willem⁶ ; Antonio Baici⁴ ; Kai Simons⁷ ; Oliver Brü ; stle⁸ ; ⁹ ; ¹⁰ ; Philipp Koch⁸ ; Christian Haass⁶ ; ⁹ ; ¹¹ ; Amedeo Caflisch⁴ ; Lawrence Rajendran¹ ; ² ; ³ ; ^{rajendran@bli.uzh.ch" class="auth_mail" title="E-mail the corresponding author}
关键词：Alzheimer disease ; APP ; BACE ; molecular dynamics ; subcellular compartmentalization ; membrane trafficking ; secretase ; amyloid ; Neuregulin
刊名：Cell Reports
出版年：2016
出版时间：8 March 2016
年：2016
卷：14
期：9
页码：2127-2141
全文大小：4271 K

文摘

•: The AD-linked protease BACE1 cleaves APP to produce toxic β-amyloid peptides
•: BACE1 also cleaves the non-amyloid substrates NRG1 and L1
•: BACE1 cleavage of NRG1 and L1 is endocytosis-independent, unlike the cleavage of APP
•: The endosomally targeted BACE1 inhibitor spares NRG1 and L1 but inhibits APP processing

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