CD4⁺ Foxp3⁺ T-cells contribute to myocardial ischemia-reperfusion injury

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• 作者：Denise Mathes ; PhD^b ; ^{denise.mathes@med.uni-jena.de} ; Johannes Weirather ; PhD^a ; ^c ; Peter Nordbeck ; MD^a ; ^c ; Anahi-Paula Arias-Loza ; PhD^a ; Matthias Burkard^a ; ^c ; Christina Pachel ; PhD^a ; ^c ; Thomas Kerkau ; MD^d ; Niklas Beyersdorf ; MD^d ; Stefan Frantz ; MD^a ; ^c ; ^e ; Ulrich Hofmann ; MD^a ; ^c ; ^e
• 关键词：Myocardial ischemia-reperfusion injury ; CD4+ T-cells ; T-regulatory cells
• 刊名：Journal of Molecular and Cellular Cardiology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：99-105
• 全文大小：935 K
• 卷排序：101

文摘

Infarct size is reduced in the absence of CD4+ T-cells after myocardial IR. Microvascular reperfusion is better in the absence of CD4+ T-cells after IR injury. Ejection fraction is better in the absence of CD4+ T-cells after myocardial IR. Presence of endogenous Foxp3+ CD4+ T-cells enhances myocardial IR injury.