The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins

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The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins

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作者：Ning Li¹ ; ¹³ ; Maryam Yousefi⁹ ; ¹³ ; Angela Nakauka-Ddamba¹³ ; Fan Li⁵ ; ⁸ ; Lee Vandivier⁵ ; ⁹ ; Kimberly Parada¹³ ; Dong-Hun Woo¹³ ; Shan Wang¹ ; ¹³ ; Ammar S. Naqvi⁵ ; Shilpa Rao⁶ ; John Tobias⁶ ; Ryan J. Cedeno⁹ ; ¹³ ; Gerard Minuesa³ ; Katz Y² ; Trevor S. Barlowe³ ; Alexander Valvezan⁹ ; ¹⁰ ; Sheila Shankar¹³ ; Raquel P. Deering² ; Peter S. Klein⁹ ; ¹⁰ ; ¹² ; Shane T. Jensen⁷ ; Michael G. Kharas³ ; Brian D. Gregory⁵ ; ⁸ ; Zhengquan Yu¹ ; ^{zyu@cau.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Christopher J. Lengner⁴ ; ⁹ ; ¹¹ ; ¹² ; ¹³ ; ^{lengner@vet.upenn.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2015
出版时间：22 December 2015
年：2015
卷：13
期：11
页码：2440-2455
全文大小：6609 K

文摘

•: RNA-binding proteins Msi1 and/or Msi2 are required for colorectal cancer
•: Msi1/2 are functionally redundant with similar target transcripts
•: Msi proteins function independently of β-catenin to promote tumorigenesis

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