A Finer Print Than TADs: PRC1-Mediated Domains

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• 作者：Elena Torlai Triglia¹ ; Tiago Rito¹ ; Ana Pombo¹ ; ^{ana.pombo@mdc-berlin.de}
• 关键词：Polycomb repressive complex ; PRC1-mediated domains ; Phc1 ; Polycomb bodies ; genome architecture ; chromatin folding ; 5C ; STORM ; embryonic stem cells ; neural progenitors
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：373-375
• 全文大小：132 K
• 卷排序：65

文摘

Polycomb proteins are well-known epigenetic repressors with unexplained roles in chromatin folding. In this issue of Molecular Cell, Kundu et al. (2017) investigate the structures of PRC1-mediated domains in stem cells and probe their changes upon differentiation and in PRC knockouts.