Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine

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• 作者：L. van Andel^a ; ^{l.v.andel@nki.nl} ; Z. Zhang^b ; S. Lu^b ; V. Kansra^b ; S. Agarwal^b ; L. Hughes^b ; M.M. Tibben^a ; A. Gebretensae^a ; H. Rosing^a ; J.H.M. Schellens^c ; ^d ; J.H. Beijnen^a ; ^d
• 关键词：ACN ; acetonitrile ; BER ; base excision repair ; C.V. ; coefficient of variation ; DMSO ; dimethylsulfoxide ; DSB ; double strand break ; EMA ; European Medicine Agency ; FDA ; Food and Drug Administration ; GLP ; Good Laboratory Practice ; HRR ; homologous recombination repair ; IS ; internal standard ; LC&ndash ; MS/MS ; liquid chromatography &ndash ; tandem mass spectrometry ; LLOQ ; lower limit of quantification ; MeOH ; methanol ; MF ; matrix factor ; MRM ; multiple reaction monitoring ; NHEJ ; non-homologous end joining
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：1040
• 期：Complete
• 页码：14-21
• 全文大小：848 K
• 卷排序：1040

文摘

The first reported validated LC–MS/MS assay for niraparib and its metabolite M1. The assay has successfully been validated in the 1–500 and 1–100 ng/mL ranges. The assay was successfully used for a bioavailability study and a mass balance study.