Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes

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Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes

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作者：Si Wang¹ ; ² ; Xiuxia Wang¹ ; Longfei Ma¹ ; ³ ; Xiwen Lin¹ ; Daoqin Zhang¹ ; ³ ; Zhen Li¹ ; ³ ; Yujian Wu¹ ; Chunwei Zheng¹ ; ³ ; Xue Feng¹ ; ⁴ ; Shangying Liao¹ ; Yanmin Feng¹ ; ³ ; Jian Chen¹ ; ³ ; Xiangjing Hu¹ ; ³ ; Min Wang¹ ; ⁵ ; Chunsheng Han¹ ; ^{hancs@ioz.ac.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：spermatogonial stem cells ; spermatocytes ; Sertoli cells ; meiosis ; retinoic acid
刊名：Stem Cell Reports
出版年：2016
出版时间：12 July 2016
年：2016
卷：7
期：1
页码：80-94
全文大小：5049 K

文摘

•: Retinoic acid (RA) is sufficient for the induction of spermatocytes
•: RA activates meiotic genes while repressing genes for SSC self-renewal
•: An in vitro model for meiosis based on RA and pup Sertoli cells is established
•: Genes for meiosis have been identified using the in vitro model

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