Schistosoma antigens downregulate CXCL9 production by PBMC of HTLV-1-infected individuals

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• 作者：Luciane Mota Lima^a ; ^{llmmll10@gmail.com} ; Luciana Santos Cardoso^a ; ^b ; ^g ; Silvane Braga Santos^a ; Ricardo Riccio Oliveira^a ; ^c ; Sé ; rgio Costa Oliveira^d ; Alfredo Miranda Gó ; es^d ; Alex Loukas^e ; Maria Ilma Araujo^a ; ^f ; ^g
• 关键词：HTLV-1 ; Schistosoma proteins ; CXCL9 ; CXCL10
• 刊名：Acta Tropica
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：157-162
• 全文大小：764 K
• 卷排序：167

文摘

Schistosoma antigens rSm29 and rSh-TSP-2 reduce the levels of CXCL9 in supernatants of PBMCs of individuals with HTLV-1. Schistosoma Antigens downregulate the levels of CXCL9 and induced high level of IL-10 in PBMC culture of HTLV-1-infected individuals. Schistosoma antigens are able to supress in vitro the levels os proinflammatory chemokines involved in the pathology of HTLV-1 infection.