Nodularin induces tumor necrosis factor-alpha and mitogen-activated protein kinases (MAPK) and leads to induction of endoplasmic reticulum stress

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Nodularin induces tumor necrosis factor-alpha and mitogen-activated protein kinases (MAPK) and leads to induction of endoplasmic reticulum stress

详细信息查看全文

作者：Nicole Meili^a ; ¹ ; Verena Christen^a ; ¹ ; Karl Fent^a ; ^b ; ^{karl.fent@fhnw.ch" class="auth_mail" title="E-mail the corresponding author} ; ^{karl.fent@bluewin.ch" class="auth_mail" title="E-mail the corresponding author}
关键词：Nodularin ; ER stress response ; TNF-α ; MAPK signalling
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：1 June 2016
年：2016
卷：300
期：Complete
页码：25-33
全文大小：1063 K

文摘

class="label">•: Toxicity of nodularin and its mechanisms of action are poorly understood.
class="label">•: We investigated mechanisms of nodularin toxicity in human liver cell lines and human hepatocytes.
class="label">•: We identified several pathways involved in nodularin toxicity.
class="label">•: Nodularin induces TNF-α, MAPK pathway and ER stress
class="label">•: These activated pathways may contribute to the hepatotoxic and tumorigenic action of nodularin.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.