Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress

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Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress

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作者：Susanne Faltermann^a ; ^c ; Verena Grundler^b ; Karl Gademann^b ; Jakob Pernthaler^c ; Karl Fent^a ; ^d ; ^{karl.fent@fhnw.ch" class="auth_mail" title="E-mail the corresponding author} ; ^{karl.fent@bluewin.ch" class="auth_mail" title="E-mail the corresponding author}
关键词：Cyanobacterial toxin ; Microcystin ; Nodularin ; Endoplasmic reticulum stress ; Zebrafish ; Liver organ culture
刊名：Aquatic Toxicology
出版年：2016
出版时间：February 2016
年：2016
卷：171
期：Complete
页码：77-87
全文大小：2566 K

文摘

class="label">•: The aim was to investigate the uptake and effects of cyanotoxins in zebrafish.
class="label">•: Transcripts of organic anionic uptake transporter polypeptides (Oatp) occurred in embryos.
class="label">•: Fluorescently labeled MC-LR accumulated in the glomerulus of pronephros of embryos.
class="label">•: Both MC-LR and nodularin induced ER-stress and TNFα in liver organ cultures.
class="label">•: Microcystin-LR and nodularin did not induce measurable transcriptional effects in eleuthero-embryos.