Preparation of core/shell NaYF₄:Yb,Tm@dendrons nanoparticles with enhanced upconversion luminescence for in vivo imaging

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• 作者：Nadè ; ge Francolon ; PhD^a ; Damien Boyer ; PhD^a ; ^{damien.boyer@sigma-clermont.fr" class="auth_mail" title="E-mail the corresponding author} ; Felicia Leccia ; PhD^b ; Elodie Jouberton ; MS^c ; ^d ; Auré ; lie Walter ; PhD^e ; Catalina Bordeianu ; MS^e ; Audrey Parat ; PhD^e ; Delphine Felder-Flesch ; PhD^e ; Sylvie Begin-Colin ; PhD^e ; Elisabeth Miot-Noirault ; PhD^c ; Jean-Michel Chezal ; PhD^c ; Rachid Mahiou ; PhD^a
• 关键词：Nanoparticle ; Upconversion ; Dendrons ; Fluorescence imaging
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：12
• 期：7
• 页码：2107-2113
• 全文大小：868 K

文摘

Upconverting nanoparticles (UCNPs) were successfully dendronized for fluorescence medical imaging applications. The structural and morphological characterizations of resulting core/shell NaYF₄:Yb,Tm@dendrons nanoparticles were performed by means of X-ray diffraction, infrared spectroscopy and transmission electron microscopy. In vitro cytotoxicity assays have evidenced their low toxicity. In vivo fluorescence imaging study was performed in mice upon IR excitation, showing promising imaging capacities at low concentrations (0.5 mg/mL) and low power (50 mW/cm²).