A simple predictive model for postoperative mortality after head and neck cancer surgery with opening of mucosa

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• 作者：Nicolas Penel ; Eric Yaovi Amela ; Yann Mallet ; Daniè ; le Lefebvre ; Sté ; phanie Clisant ; Ahmed Kara ; Jean-Charles Neu ; Fré ; dé ; ric Everard ; Jean-Louis Lefebvre
• 刊名：Oral Oncology
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：43
• 期：2
• 页码：174-180
• 全文大小：119 K

文摘

Summary

The aim of this study was to determine the risk factors for the mortality during the first 30 days after a major head and neck cancer surgery. Two hundred and sixty one consecutive surgical procedure were prospectively studied at Oscar Lambret Cancer Centre within a 36-months period. Twenty variables were recorded for each patient. The significant risk factors for postoperative mortality were assessed by univariate and multivariate analysis. Overall 30-days mortality rate was 3.83 % [95 % CI 3.13–4.53]. In univariate analysis identified four risk factors: female gender (odd ratio 4.25 [95 % CI 1.03–17.56]), age equal or superior than 70 (odd ratio 5.06 [95 % CI 1.35–18.36]), current alcohol addiction (odd ratio 3.65 [1.02–13.06]) and laryngeal location (odd ratio 4.23 [CI 95 % 1.18–3.38]). In multivariate analysis only female gender and laryngeal location remained significant. The incidence of postoperative mortality was 1.63 % for patients without risk factor and was 6.41 % for those with one or two risk factors. This model identifies easily high-risk patients for major head and neck cancer surgery. A multicenter validation is necessary.