An altered redox balance and increased genetic instability characterize primary fibroblasts derived from xeroderma pigmentosum group A patients

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An altered redox balance and increased genetic instability characterize primary fibroblasts derived from xeroderma pigmentosum group A patients

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作者：Eleonora Parlanti^a ; Donatella Pietraforte^b ; Egidio Iorio^b ; Sergio Visentin^b ; Chiara De Nuccio^b ; Andrea Zijno^a ; Mariarosaria D&rsquo ; Errico^a ; Valeria Simonelli^a ; Massimo Sanchez^b ; Paola Fattibene^c ; Mario Falchi^d ; Eugenia Dogliotti^a ; ^{dogliotti@iss.it" class="auth_mail" title="E-mail the corresponding author}
关键词：acet ; acetate ; ala ; alanine ; ANOVA ; analysis of variance ; asp ; asparagine ; BER ; base excision repair ; BSO ; buthionine sulphoximine ; CAT ; catalase ; Cho ; choline ; CPD ; cyclobutane pyrimidine dimers ; CS ; cockayne syndrome ; CPH ; 1-hydroxy-3-carboxy-2 ; 2 ; 5 ; 5-tetramethylpyrrolidine ; DTPA ; diethylenetriamine pentaacetic acid ; EPR ; electromagnetic paramagnetic resonance ; GGR ; global genome repair ; gln ; glutamine ; glt ; glutamate ; GPCho ; glycerophosphocholine ; GS ; glutathione ; GSH ; reduced glutathione ; GSS
刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
出版年：2015
出版时间：December 2015
年：2015
卷：782
期：Complete
页码：34-43
全文大小：1929 K

文摘

bel">•: Increased levels and different types of intracellular radical species as well as an altered glutathione redox state characterize XP-A human cells when compared to normal.
bel">•: A more glycolytic metabolism and higher ATP levels are associated with alteration of mitochondrial morphology and response to mitochondrial toxicants when XPA is defective.
bel">•: XP-A human cells show increased spontaneous micronuclei frequency, a hallmark of cancer risk.

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