Somatostatin receptor 5 is a prominent regulator of signaling pathways in cells with coexpression of Cannabinoid receptors 1

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• 作者：Shenglong Zou ; Rishi K. Somvanshi ; Ujendra Kumar ; ^{ujendra.kumar@ubc.ca}
• 关键词：AD ; Alzheimer&rsquo ; s disease ; cAMP ; cyclic adenosine monophosphate ; CB1R ; Cannabinoid receptor 1 ; CNS ; central nervous system ; co-IP ; co-immunoprecipitation ; Cy3 ; cyanine 3 ; D2R ; dopamine receptor 2 ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; FITC ; fluorescein isothiocyanate ; FSK ; forskolin ; GPCR ; G protein-coupled receptor ; HA ; hemagglutinin ; hCB1R ; human cannabinoid receptor 1 ; HD ; Huntington&rsquo ; s disease ; hSSTR5 ; human somatostatin receptor 5 ; IBMX ; 3-isobutyl-1-methylxanthine ; PA
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：218-231
• 全文大小：3093 K
• 卷排序：340

文摘

SSTR5 and CB1R exist as constitutive heterodimers in rat brain regions and cotransfected HEK-293 cells. Concurrent receptor activation leads to preferential disruption of SSTR5/CB1R heterodimer and formation of SSTR5 homodimer. SSTR5 plays the major role in the regulation of cAMP/PKA/ERK1/2 signaling pathways in cotransfected cells. Time course of PI3K phosphorylation is altered upon concurrent receptor activation.