A review of molecular genetic studies of neurocognitive deficits in schizophrenia

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• 作者：Gwyneth Zai^a ; ^b ; ^c ; ^d ; ^{gwyneth.zai@camh.ca} ; Trevor W. Robbins^c ; ^e ; Barbara J. Sahakian^c ; ^d ; James L. Kennedy^a ; ^b
• 关键词：Genetics ; Schizophrenia ; Neurocognition ; Cognitive deficits ; Candidate gene studies ; Genome-wide association studies (GWASs)
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：50-67
• 全文大小：1829 K
• 卷排序：72

文摘

Schizophrenia patients present with impaired cognitive functions. Evidence suggests strong genetic etiology for cognitive deficits in schizophrenia. Neurotransmitter system genes showed effect on cognitive deficits in schizophrenia. Limited evidence suggests the dopaminergic system genes with inconsistent findings. Larger samples are required to examine genetic risk of cognition in schizophrenia.