Tendon-derived stem cells undergo spontaneous tenogenic differentiation

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Tendon-derived stem cells undergo spontaneous tenogenic differentiation

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作者：Jia Guo^a ; Kai-Ming Chan^a ; ^b ; ^c ; ^d ; Jin-Fang Zhang^a ; ^b ; ^e ; ^{zhangjf06@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author} ; Gang Li^a ; ^b ; ^c ; ^d ; ^e ; ^{gangli@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author}
关键词：TDSC ; Tendon-derived stem cell ; ECM ; Extracellular matrix ; BMSCs ; Bone marrow mesenchymal stem cells ; Scx ; Scleraxis ; Mkx ; Mohawk homeobox ; Egr1 ; Early growth response 1 ; Eya1 ; Eyes absent homolog 1 ; NS ; Nucleostemin ; EphA4 ; Ephrin type-A receptor 4 ; Col3a1 ; Collagen type III ; Lox ; Lysyl oxidase ; TenC ; Tenascin C ; Col1a1 ; Collagen type I ; Tnmd ; Tenomodulin ; Dcn ; Decorin ; Fmod ; Fibromodulin ; Bgn ; Biglycan ; PAI-1 ; Plasminogen activator inhibitor type 1
刊名：Experimental Cell Research
出版年：2016
出版时间：1 February 2016
年：2016
卷：341
期：1
页码：1-7
全文大小：1650 K

文摘

•: TDSCs had the potential of spontaneous tenogenic differentiation.
•: The tenogenic transcription factors were upregulated during this process.
•: The expression of ECM and other tendon markers was promoted during this process.
•: The collagen synthesis ability was also increased during this process.

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