• 作者：Kelly L. Stratton ; M.D.^a ; ^b ; Shaheen Alanee ; M.D. ; M.P.H. ; M.B.A.^c ; ^{salanee@siumed.edu" class="auth_mail" title="E-mail the corresponding author} ; Emily A. Glogowski ; M.S. ; M.Sc. ; C.G.C.^a ; Kasmintan A. Schrader ; M.B.B.S.^a ; Rohini Rau-Murthy ; B.S.^a ; Robert Klein ; Ph.D.^a ; Paul Russo ; M.D.^a ; Jonathan Coleman ; M.D.^a ; Kenneth Offit ; M.D. ; M.P.H.^a ; ^b
• 关键词：Kidney cancer ; Inherited cancer syndromes ; Genetic testing
• 刊名：Urologic Oncology: Seminars and Original Investigations
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：34
• 期：5
• 页码：238.e1-238.e7
• 全文大小：576 K

d="p0005">We identified several factors that may predict positive test results in patients with kidney cancer undergoing evaluation in a clinical genetics clinic. Although these risk factors have previously been associated with cancer syndromes, a need for studies of testing practices remains.

d="p0010">Our data suggest that in patients with kidney cancer evaluated for hereditary cancer syndromes, young age is associated with diagnosis of RCC syndromes, whereas syndromic manifestations and multiple primaries are found in Lynch syndrome.

d="p0015">These results, along with clinical pathway, suggested for evaluating patients with kidney cancer for inherited cancer syndrome may be useful for practicing urologists to select patients with kidney cancer to refer for genetic counseling.