Protein aggregation and ER stress

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Protein aggregation and ER stress

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作者：Navit Ogen-Shtern^a ; ^b ; Tamuz Ben David^a ; ^b ; Gerardo Z. Lederkremer^a ; ^b ; ^{gerardo@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author}
关键词：Aβ ; (β-amyloid peptide) ; AD ; (Alzheimer's disease) ; ALS ; (Amyotrophic Lateral Sclerosis) ; APP ; (amyloid precursor protein) ; ATF6 ; (activating transcription factor 6) ; CNX ; (calnexin) ; eIF2α ; (Eukaryotic Initiation Factor 2 α ; ER ; (endoplasmic reticulum) ; ERAD ; (ER-associated degradation) ; ERQC ; (ER-derived quality control compartment) ; HD ; (Huntington's disease) ; Htt ; (Huntingtin) ; IRE1 ; (inositol requiring 1) ; MAM ; (ER-mitochondria associated membranes) ; NDs ; (neurodegenerative diseases) ; PD ; (
刊名：Brain Research
出版年：2016
出版时间：1 October 2016
年：2016
卷：1648
期：part_PB
页码：658-666
全文大小：927 K

文摘

•: Protein aggregation is a main feature of most of the neurodegenerative diseases.
•: The toxic species are oligomeric forms and not the final amyloid aggregates.
•: ER stress develops, is a major cause of disease and could be a therapeutic target.

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