A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection

详细信息    查看全文

• 作者：Mukta Dutta¹ ; ⁵ ; Shelly J. Robertson² ; ⁵ ; Atsushi Okumura¹ ; ² ; ³ ; Dana P. Scott⁴ ; Jean Chang¹ ; Jeffrey M. Weiss¹ ; Gail L. Sturdevant² ; Friederike Feldmann² ; Elaine Haddock² ; Abhilash I. Chiramel² ; Sanket S. Ponia² ; Jonathan D. Dougherty² ; Michael G. Katze¹ ; Angela L. Rasmussen¹ ; ³ ; Sonja M. Best² ; ⁶ ; ^{sbest@niaid.nih.gov}
• 关键词：Ebola virus ; MAVS ; conditional ; knockout ; interferon ; mouse adapted ; macrophages ; RLR
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：816-829
• 全文大小：7353 K
• 卷排序：18

文摘

MAVS determines early differences in replication between WT and MA Ebola virus in mice MAVS controls expression of IFN-I, inflammatory responses, and cell death MAVS signaling specifically in myeloid cells is required for control of EBOV replication MAVS has both IFN-I-dependent and -independent roles in the control of EBOV