Concise synthesis of (+)-conduritol F and inositol analogues from naturally available (+)-proto-quercitol and their glucosidase inhibitory activity

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• 作者：Wisuttaya Worawalai ; Eakkaphon Rattanangkool ; Avassaya Vanitcha ; Preecha Phuwapraisirisan ; Sumrit Wacharasindhu ; ^{sumrit.w@chula.ac.th}
• 关键词：Conduritol-F ; ¦Á-Glucosidase ; Quercitoll ; Inositol ; Diabetes mellitus
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：15 February, 2012
• 年：2012
• 卷：22
• 期：4
• 页码：1538-1540
• 全文大小：329 K

文摘

An effective synthesis of (+)-conduritol F, (+)-chiro- and (+)-epi-inositols from naturally available (+)-proto-quercitol is described. This synthetic method provides a concise synthesis of cyclitols in enantiomerically pure form. Of the synthesized cyclitols, (+)-conduritol F potently inhibits type I ¦Á-glucosidase with an IC₅₀ value of 86.1 ¦ÌM, which is five times greater than the standard antidiabetic drug, acarbose.