Peritoneal dialysis effluent miR-21 and miR-589 levels correlate with longitudinal change in peritoneal transport characteristics

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• 作者：Cheuk-Chun Szeto ; MD ; FRCP ; ^{ccszeto@cuhk.edu.hk} (Professor) ; Kai-Ming Chow ; MBChB ; FRCP(Edin) (Associate Consultant) ; Bonnie Ching-Ha Kwan ; MBBS ; FRCP(Edin) (Professional Consultant) ; Phyllis Mei-Shan Cheng ; BN ; RN (Research Nurse) ; Cathy Choi-Wan Luk ; BSc (Research Assistant) ; Jack Kit-Chung Ng ; MBChB ; MRCP(UK) (Fellow) ; Man-Ching Law ; BN ; RN (Nursing Consultant) ; Chi-Bon Leung ; MBChB ; FRCP(Edin) (Consultant) ; Philip Kam-Tao Li ; MD ; FRCP (Consultant)
• 关键词：Renal failure ; Gene expression ; Inflammation
• 刊名：Clinica Chimica Acta
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：464
• 期：Complete
• 页码：106-112
• 全文大小：1008 K
• 卷排序：464

文摘

miR-21 and miR-589 levels in peritoneal dialysis effluent showed consistently significant relation with peritoneal transport. Since these two targets are involved in the regulation of cyclooxygenase expression, our result suggests that these miRNAs may affect peritoneal transport via the prostaglandin pathway. Further studies are needed to determine the role of serial monitoring of miRNA in PD effluent.