Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice

详细信息查看全文

作者：Paula Mosińska^a ; Katarzyna Socała^b ; Dorota Nieoczym^b ; Moshe Laudon^c ; Martin Storr^d ; ^e ; Jakub Fichna^a ; Piotr Wlaź^b ; ^{piotr.wlaz@umcs.lublin.pl" class="auth_mail" title="E-mail the corresponding author}
关键词：5-HT ; serotonin ; ANOVA ; analysis of variance ; CC50 ; convulsive current inducing seizure response in 50% of mice ; CNS ; central nervous system ; DMSO ; dimethyl sulfoxide ; GABA ; γ-aminobutyric acid ; GI ; gastrointestinal ; i.p. ; intraperitoneally ; i.v. ; intravenously ; mCPP ; m-chlorophenylpiperazine ; MEST ; maximal electroshock seizure threshold ; MLT ; melatonin ; MT ; melatonin receptor ; N ; newtons ; NMDA ; N-methyl-D-aspartic acid ; NO ; nitric oxide ; PTZ ; pentylenetetrazole ; SEM ; standard error of the mean
刊名：Behavioural Brain Research
出版年：2016
出版时间：1 July 2016
年：2016
卷：307
期：Complete
页码：199-207
全文大小：1854 K

文摘

•: Neu-P11 and Neu-P67 have a prolonged duration of action and oral availability, compared to MLT.
•: MLT produced potent anticonvulsant effect in 6 Hz, MEST and PTZ tests.
•: In contrast, neither Neu-P11 nor Neu-P67 affected the seizure threshold in 6 Hz, MEST and PTZ tests.
•: Changes observed in the locomotor activity suggest the interaction of Neu-P11 and Neu-P67 in the CNS that is independent of MT.
•: Effects of MLT have yet to be explored; our studies support its potential as an anticonvulsant therapeutic.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.