Modifications of Western-type diet regarding protein, fat and sucrose levels as modulators of steroid metabolism and activity in liver

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• 作者：Agata Krawczyńska^a ; ^b ; ^{a.krawczynska@ifzz.pl} ; Andrzej P. Herman^a ; Hanna Antushevich^a ; Joanna Bochenek^a ; Katarzyna Dziendzikowska^b ; Alina Gajewska^a ; Joanna Gromadzka-Ostrowska^b
• 关键词：Aro ; Diet ; Liver ; Antioxidant system ; Srd5a1 ; Testosterone
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：331-341
• 全文大小：672 K
• 卷排序：165

文摘

The Western-type diet with decreased protein content impairs the liver antioxidant system. The lower protein level in high-fat diet decreased liver T conversion to E2 and E3. Liver Esr1 mRNA level was increased when low-protein, high-fat diet was consumed. The liver Srd5a1 and Ar gene expression is positively correlated with body weight. The fat reduction in Western-type diet restores plasma proportion between T and E2.