miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis

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miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis

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作者：Xintong Ge^a ; ^b ; ^c ; ^d ; ¹ ; Shan Huang^b ; ^c ; ^d ; ^e ; ^f ; ¹ ; Huabin Gao^b ; ^c ; ^d ; ^e ; ^f ; Zhaoli Han^e ; ^f ; Fanglian Chen^b ; ^c ; ^d ; Shishuang Zhang^e ; ^f ; Zengguang Wang^a ; Chunsheng Kang^g ; Rongcai Jiang^a ; ^b ; ^c ; ^d ; Shuyuan Yue^a ; Ping Lei^e ; ^f ; ^{leiping1974@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jianning Zhang^a ; ^b ; ^c ; ^d ; ^{jianningzhang@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：MiR-21-5p ; Blood-brain barrier ; Brain microvascular endothelial barrier ; Traumatic brain injury
刊名：Brain Research
出版年：2016
出版时间：1 November 2016
年：2016
卷：1650
期：Complete
页码：31-40
全文大小：6028 K

文摘

class="label">•: Increased miR-21-5p level in BMVECs is a protective response following TBI.
class="label">•: miR-21-5p alleviates injury-induced microvascular endothelial barrier damage.
class="label">•: miR-21-5p reduces inflammation and inhibits NF-kB signaling in injured BMVECs.
class="label">•: miR-21-5p inhibits cell apoptosis and promotes Akt signaling in injured BMVECs.
class="label">•: miR-21-5p promotes the expression of Ang-1/Tie-2 axis in injured BMVECs.

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