The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

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The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

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作者：Kuo-Hsuan Chang^a ; ¹ ; Ya-Jen Chiu^b ; ¹ ; Shu-Ling Chen^b ; ¹ ; Chen-Hsiang Huang^b ; Chih-Hsin Lin^a ; Te-Hsien Lin^b ; Chi-Mei Lee^b ; Chintakunta Ramesh^c ; Chung-Hsin Wu^b ; Chin-Chang Huang^a ; Hon-Chung Fung^a ; Yi-Chun Chen^a ; Jung-Yaw Lin^b ; Ching-Fa Yao^c ; Hei-Jen Huang^d ; Guey-Jen Lee-Chen^b ; ^{t43019@ntnu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Ming-Chung Lee^b ; ^{t43006@ntnu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Hsiu Mei Hsieh-Li^b ; ^{hmhsieh@ntnu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
关键词：Alzheimer's disease ; Aβ aggregation ; Synthetic indolylquinoline derivatives ; Therapeutics
刊名：Neuropharmacology
出版年：2016
出版时间：February 2016
年：2016
卷：101
期：Complete
页码：309-319
全文大小：2318 K

文摘

class="label">•: Indolylquinoline compounds work as chemical chaperones in Aβ-aggregation reduction.
class="label">•: Indolylquinolines suppress ROS and promote neurite outgrowth in Aβ-expressing cells.
class="label">•: Indolylquinolines provide neuroprotection in Aβ-treated mouse hippocampal cells.
class="label">•: Indolylquinolines ameliorate Aβ-induced inhibition of LTP in mouse hippocampal slices.

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