Transgenesis of humanized fat1 promotes n </ce:hsp>− </ce:hsp>3 polyunsaturated fatty acid synthesis and expression of genes involved in lipid metabolism in goat cells

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Transgenesis of humanized fat1 promotes n − 3 polyunsaturated fatty acid synthesis and expression of genes involved in lipid metabolism in goat cells

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作者：Yixuan Fan^a ; ^{fanyixuan@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Caifang Ren^a ; ^{853748688@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Zhibo Wang^b ; ^{747551898@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Ruoxin Jia^a ; ^{772674111@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Dan Wang^a ; ^{563476324@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Yanli Zhang^a ; ^{zhangyanli@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Guomin Zhang^a ; ^{645081243@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Yongjie Wan^a ; ^{wanyongjie@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Mingrui Huang^a ; ^{hmr@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Feng Wang^a ; ^{caeet@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：ACO ; acyl-coenzyme A oxidase ; ARA ; arachidonic acid ; CPT1 ; carnitine palmitoyltransferase 1 ; DHA ; docosahexaenoic acid ; DPA ; docosapentaenoic acid ; ELOVL2 ; elongase-2 ; ELOVL5 ; elongase-5 ; EPA ; eicosapentaenoic acid ; FADS1 ; fatty acid desaturase-1 ; FADS2 ; fatty acid desaturase-2 ; GEFCs ; goat ear skin-derived fibroblast cells ; LA ; linoleic acid ; PPARα ; peroxisome proliferator-activated receptor alpha ; PPARγ ; peroxisome proliferator-activated receptor gamma ; PUFAs ; polyunsaturated fatty acids ; SREB
刊名：Gene
出版年：2016
出版时间：15 January 2016
年：2016
卷：576
期：1
页码：249-255
全文大小：574 K

文摘

•: A eukaryotic vector of fat1 was constructed and can be efficiently expressed in GEFCs.
•: The expression of fat1 in GEFCs resulted in a significant increase of n − 3 PUFAs.
•: Fat1-overexpression altered expression of PUFA synthesis related genes in GEFCs.