Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

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Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

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作者：Jessica Brandi^a ; Ilaria Dando^b ; Elisa Dalla Pozza^b ; Giulia Biondani^b ; Rosalind Jenkins^c ; Victoria Elliott^d ; Kevin Park^c ; Giuseppina Fanelli^e ; Lello Zolla^e ; Eithne Costello^d ; Aldo Scarpa^f ; Daniela Cecconi^a ; ^{daniela.cecconi@univr.it" class="auth_mail" title="E-mail the corresponding author} ; Marta Palmieri^b
关键词：Pancreatic cancer ; Cancer stem cells ; Pancreatic ductal adenocarcinoma PDAC
刊名：Journal of Proteomics
出版年：2017
出版时间：6 January 2017
年：2017
卷：150
期：Complete
页码：310-322
全文大小：1854 K

文摘

class="label">•: iTRAQ proteomic analysis of pancreatic cancer stem cells (Panc1 CSCs)
class="label">•: Identification of 230 differentially expressed proteins of Panc1 CSCs
class="label">•: Activation of glycolysis, pentose phosphate pathway, pyruvate-malate cycle, and lipid metabolism
class="label">•: Downregulation of Krebs cycle, spliceosome and non homologous end joining
class="label">•: Fatty acids synthesis and mevalonate pathways directly involved in Panc1 CSCs viability

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