Long-term exposure to black carbon, cognition and single nucleotide polymorphisms in microRNA processing genes in older men

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Long-term exposure to black carbon, cognition and single nucleotide polymorphisms in microRNA processing genes in older men

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作者：Elena Colicino^a ; ^{ecolicin@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Giulia Giuliano^a ; ^{g.giuliano6@campus.unimib.it" class="auth_mail" title="E-mail the corresponding author} ; Melinda C. Power^a ; ^b ; ^{melinda.c.power@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Johanna Lepeule^a ; ^{jlepeule@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Elissa H. Wilker^a ; ^c ; ^{ewilker@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Pantel Vokonas^d ; ^{pantel.vokonas@va.gov" class="auth_mail" title="E-mail the corresponding author} ; Kasey J.M. Brennan^a ; ^{kbrennan@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Serena Fossati^a ; ^e ; ^{sfossati@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Mirjam Hoxha^f ; ^g ; ^{mirjam.hoxha@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Avron Spiro III^d ; ^{aspiro3@bu.edu" class="auth_mail" title="E-mail the corresponding author} ; Marc G. Weisskopf^a ; ^b ; ^{mweissko@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Joel Schwartz^a ; ^b ; ^{joel@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Andrea A. Baccarelli^a ; ^b ; ^{abaccare@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：BC ; black carbon ; CERAD ; Consortium to Establish a Registry for Alzheimer Disease ; CI ; confidence interval ; WAIS-R ; Wechsler Adult Intelligence Scales for Adults ; Revised ; FDR ; False Discovery Rate ; miRNA ; microRNA ; mRNA ; messenger RNA ; MET-hr ; metabolic equivalent hours ; MMSE ; Mini-Mental State Examination ; NAS ; Normative Aging Study ; nt ; nucleotide ; OR ; odds ratio ; pri-miRNA ; primary-miRNA ; RISC ; RNA-induces silencing complex ; RNA ; Ribonucleic Acid ; SD ; standard deviation ; SNP ; single nucleoti
刊名：Environment International
出版年：2016
出版时间：March 2016
年：2016
卷：88
期：Complete
页码：86-93
全文大小：362 K

文摘

class="label">•: Black carbon (BC), marker of air pollution, was adversely associated with cognition.
class="label">•: SNPs in miRNA processing-genes were adversely associated with cognition.
class="label">•: SNPs in miRNA processing-genes affected susceptibility to BC–cognition association.
class="label">•: Susceptibility possibly due to influences on miRNA expression