DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice

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DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice

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作者：Degui Wang^a ; ^{wangdegui@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Tianyu Yu^a ; Yongqiang Liu^a ; Jun Yan^a ; Yingli Guo^a ; Yuhong Jing^a ; Xuguang Yang^a ; Yanfeng Song^a ; ^{songyanfeng@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yingxia Tian^b ; ^{tianyxlz@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Parkinson's disease ; DNA damage ; Neurodegeneration ; α-Synuclein ; Mouse
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：2 December 2016
年：2016
卷：481
期：1-2
页码：104-110
全文大小：1914 K

文摘

class="label">•: This study explore contribution of DNA damage to neurodegeneration in Parkinson's disease mice.
class="label">•: A53T-α-Syn MEF cells show a prolonged DNA damage repair process and senescense phenotype.
class="label">•: DNA damage preceded onset of motor phenotype in A53T-α-Syn transgenic mice.
class="label">•: DNA damage decrease the number of nigrostriatal dopaminergic neurons.
class="label">•: Neurons of A53T-α-Syn transgenic mice are more fragile to DNA damages.

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