Olfactory impairment predicts cognitive decline in early Parkinson's disease

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Olfactory impairment predicts cognitive decline in early Parkinson's disease

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作者：Michelle E. Fullard^a ; ^b ; ¹ ; ^{michelle.fullard@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; Baochan Tran^b ; ¹ ; ^{Baochan.Tran@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; Sharon X. Xie^c ; ^{sxie@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; Jon B. Toledo^b ; ^d ; ^{jtoledo@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; Christi Scordia^b ; ^{Christi.Scordia@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; Carly Linder^b ; ^{Carly.Linder@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; Rachael Purri^b ; ^{Rachael.Purri@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; Daniel Weintraub^a ; ^b ; ^e ; ^{Daniel.Weintraub@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; John E. Duda^a ; ^b ; ^{john.duda@med.va.gov" class="auth_mail" title="E-mail the corresponding author} ; Lama M. Chahine^b ; ¹ ; ^{Lama.chahine@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author} ; James F. Morley^a ; ^b ; ¹ ; ^{James.Morley@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Parkinson's disease ; Olfaction ; Mild cognitive impairment ; Non-motor symptoms ; Cerebrospinal fluid
刊名：Parkinsonism & Related Disorders
出版年：2016
出版时间：April 2016
年：2016
卷：25
期：Complete
页码：45-51
全文大小：616 K

文摘

class="label">•: Olfactory impairment is common in Parkinson's disease.
class="label">•: Lower UPSIT score was associated with more severe non-motor symptoms.
class="label">•: Worse olfaction was associated with a greater decline in MoCA score.
class="label">•: Addition of AD CSF biomarkers to olfaction may improve ability to predict MCI.