Prognosis of schizophrenia spectrum disorder may not be predetermined during early development - the Northern Finland Birth Cohort 1966

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• 作者：Nina Rautio^a ; ^b ; ^{nina.rautio@oulu.fi" class="auth_mail" title="E-mail the corresponding author} ; Juha Kä ; kelä ; ^a ; ^c ; ^d ; ^{juha.kakela@student.oulu.fi" class="auth_mail" title="E-mail the corresponding author} ; Tanja Nordströ ; m^a ; ^d ; ^{tanja.nordstrom@oulu.fi" class="auth_mail" title="E-mail the corresponding author} ; Jouko Miettunen^a ; ^c ; ^d ; ^e ; ^{jouko.miettunen@oulu.fi" class="auth_mail" title="E-mail the corresponding author} ; Sirkka Keinä ; nen-Kiukaanniemi^a ; ^b ; ^{sirkka.keinanen-kiukaanniemi@oulu.fi" class="auth_mail" title="E-mail the corresponding author} ; Leena Ala-Mursula^a ; ^{leena.ala-mursula@oulu.fi" class="auth_mail" title="E-mail the corresponding author} ; Jaro Karppinen^a ; ^d ; ^{jaro.karppinen@oulu.fi" class="auth_mail" title="E-mail the corresponding author} ; Matti Penttilä ; ^c ; ^d ; ^e ; ^{matti.penttila@oulu.fi" class="auth_mail" title="E-mail the corresponding author} ; Erika Jä ; ä ; skelä ; inen^a ; ^c ; ^d ; ^{erika.jaaskelainen@oulu.fi" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Schizophrenia ; Employment ; Hospitalization ; Early predictors
• 刊名：Schizophrenia Research
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：173
• 期：1-2
• 页码：62-68
• 全文大小：284 K

文摘

Little is known about whether factors during the first years of life predict later outcomes in schizophrenia spectrum disorder (SSD). As part of the Northern Finland Birth Cohort 1966, we examined if prospectively collected early parenthood-related and developmental factors predict employment and hospitalization in individuals with and without SSD.

Methods

Overall, 161 individuals with SSD and 10,116 without SSD were included in the study. Outcomes were analysed at age of 44–45 years, defining “employment” as being employed for at least 25% of working days and “hospitalization” as having psychiatric hospitalization at least once during the last two years of follow-up. Maternal age, wantedness of pregnancy, grand multiparity, parental psychoses, birth weight, birth height, age of standing up and standing and walking without support were analysed as predictors.

Results

Of the individuals with SSD, only 11.2% were employed, although 77.6% remained not hospitalized. In individuals with SSD, only young maternal age was associated with lower probability (OR 0.25, CI 0.08–0.77) of being non-hospitalized after controlling for sex and onset age of illness. Among persons without SSD, almost all parenthood-related and developmental factors were related to employment, while grand multiparity and parental psychosis were related to hospitalization after controlling for sex.

Conclusions

Only one of the early parenthood-related and developmental factors analysed in this study predicted outcome in individuals with SSD, while among those without SSD almost all factors were related to employment. Thus, prognosis of SSD does not seem to be predetermined much by early development.