Reorganization of motor cortex and impairment of motor performance induced by hindlimb unloading are partially reversed by cortical IGF-1 administration

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Reorganization of motor cortex and impairment of motor performance induced by hindlimb unloading are partially reversed by cortical IGF-1 administration

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作者：Julien Mysoet^a ; ^{j.mysoet@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marie-Hé ; lè ; ne Canu^a ; ^{marie-helene.canu@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author} ; Christophe Gillet^b ; ^{christophe.gillet@univ-valenciennes.fr" class="auth_mail" title="E-mail the corresponding author} ; Julie Fourneau^a ; ^{julie.fourneau@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author} ; Cyril Garnier^b ; ^{cyril.garnier@univ-valenciennes.fr" class="auth_mail" title="E-mail the corresponding author} ; Bruno Bastide^a ; ^{bruno.bastide@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author} ; Erwan Dupont^a ; ^{erwan.dupont@univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：BDNF ; brain derived neurotrophic factor ; C ; control ; GABA ; γ-aminobutyric acid ; HU ; hindlimb unloading ; IGF-1 ; insulin-like growth factor 1
刊名：Behavioural Brain Research
出版年：2017
出版时间：15 January 2017
年：2017
卷：317
期：Complete
页码：434-443
全文大小：1892 K

文摘

class="label">•: Sensorimotor restriction affects organization of motor cortex.
class="label">•: Sensorimotor restriction induces a degradation of motor performance.
class="label">•: IGF-1 partially reverses cortical shrinkage and decrease in cortical excitability.
class="label">•: IGF-1 prevents the degradation of spontaneous activity.
class="label">•: IGF-1 has only a weak effect on challenged and overground locomotion.