Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running

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Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running

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作者：Gregory N. Ruegsegger^a ; Jacob D. Brown^b ; M. Cathleen Kovarik^a ; Dennis K. Miller^c ; Frank W. Booth^a ; ^c ; ^d ; ^e ; ^{boothf@missouri.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：ACSF ; artificial cerebrospinal fluid ; DS ; dorsal striatum ; ECN ; external cuneate nucleus ; HVR ; high voluntary running ; LVR ; low voluntary running ; MSNs ; medium spiny neurons ; NAc ; nucleus accumbens ; PWL ; paw-withdrawal latency ; VTA ; ventral tegmental area
刊名：Neuroscience
出版年：2016
出版时间：17 December 2016
年：2016
卷：339
期：Complete
页码：525-537
全文大小：1725 K

文摘

class="label">•: Intrinsic Oprm1 function was increased in the NAc of HVR compared to LVR rats.
class="label">•: Intraperitoneal naltrexone reduced dopamine-related mRNAs, running and free feeding in HVR but not LVR rats.
class="label">•: 6-OHDA infusion in the NAc ablated naltrexone-induced reductions in running in HVR rats.
class="label">•: 6-OHDA infusion in the NAc did not effect free food intake in HVR rats.
class="label">•: Opioid signaling may influence running motivation in a dopamine-dependent manner.

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