White mold (Sclerotinia sclerotiorum), friend or foe: Cytotoxic and mutagenic activities in vitro and in vivo

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White mold (Sclerotinia sclerotiorum), friend or foe: Cytotoxic and mutagenic activities in vitro and in vivo

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作者：Luciana Azevedo^a ; ^{luciana.azevedo@unifal-mg.edu.br" class="auth_mail" title="E-mail the corresponding author} ; Daniela Aparecida Chagas-Paula^b ; ^{daniela.chagas@unifal-mg.edu.br" class="auth_mail" title="E-mail the corresponding author} ; Hyemee Kim^c ; ^{kimhyemee@tamu.edu" class="auth_mail" title="E-mail the corresponding author} ; Aline Cristina Monteiro Roque^a ; ^{alinecmroque@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kris Simone Tranches Dias^b ; ^{krissimone@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author} ; Jose Cruz Machado^d ; ^{machado@dfp.ufla.br" class="auth_mail" title="E-mail the corresponding author} ; Marisi Gomes Soares^b ; ^{marisigs@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Susanne U. Mertens-Talcott^e ; ^{smtalcott@tamu.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Sclerotinia sclerotiorum ; Sclerotia ; Fungus ; NMR ; Mutagenicity ; DNA-damage ; Micronuclei test ; Comet assay ; PCR
刊名：Food Research International
出版年：2016
出版时间：February 2016
年：2016
卷：80
期：Complete
页码：27-35
全文大小：755 K

文摘

class="label">•: Aqueous extract of S.sclerotiorum (AESS) stimulates apoptotic and oxidative effects.
class="label">•: AESS increases mutagenic effects up to 288%, according to micronucleus test in vivo.
class="label">•: AESS IC₅₀ in non-cancer cells (0.016 ppm) is higher than in cancer cells (0.05 ppm).
class="label">•: A chemical profile of alkaloids and isocoumarins was determined.

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