Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats

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Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats

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作者：Ezia Guatteo^a ; ^b ; ^{e.guatteo@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author} ; Francesca Romana Rizzo^a ; ^c ; ^{rizzo.francescaromana@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mauro Federici^a ; ^{m.federici@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author} ; Alberto Cordella^a ; ^c ; ^{alberto_cordella@live.it" class="auth_mail" title="E-mail the corresponding author} ; Ada Ledonne^a ; ^{adaledonne@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Laura Latini^a ; ^{l.latini@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author} ; Annalisa Nobili^a ; ^f ; ^{nobili.annalisa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Maria Teresa Viscomi^a ; ^{mt.viscomi@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author} ; Filippo Biamonte^d ; ^{filippo.biamonte@rm.unicatt.it" class="auth_mail" title="E-mail the corresponding author} ; Kerstin K. Landrock^e ; ^{KLandrock@cvm.tamu.edu" class="auth_mail" title="E-mail the corresponding author} ; Alessandro Martini^a ; ^c ; ^{alex1martini@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Daniela Aversa^a ; ^c ; ^{daniela.biotech@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Chiara Schepisi^a ; ^{chiara.schepisi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marcello D'Amelio^a ; ^f ; ^{m.damelio@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author} ; ^{m.damelio@unicampus.it" class="auth_mail" title="E-mail the corresponding author} ; Nicola Berretta^a ; ^{n.berretta@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author} ; Nicola B. Mercuri^a ; ^c ; ^{mercurin@med.uniroma2.it" class="auth_mail" title="E-mail the corresponding author}
关键词：α-syn ; α-synuclein ; m/m ; homozygous mutant rats ; ; +/+ ; ; control animals ; PD ; Parkinson's disease ; LBs ; Lewy bodies ; SNpc ; substantia nigra pars compacta ; VTA ; ventral tegmental area ; DA ; dopamine ; DAergic neurons ; dopaminergic neurons ; MSNs ; medium spiny neurons ; MEA ; multi-electrode array ; CPA ; constant potential amperometry ; DAT ; dopamine transporter ; HCN ; hyperpolarization-activated cyclic nucleotide-gated channels ; GIRK ; G-protein coupled inward rectifier potassium channels ; MPH ; m
刊名：Experimental Neurology
出版年：2017
出版时间：January 2017
年：2017
卷：287
期：part_P1
页码：21-33
全文大小：1629 K

文摘

class="label">•: α-syn accumulates in the mesencephalon, striatum and frontal cortex of m/m rats.
class="label">•: SNpc DAergic neurons from m/m rats show normal functional activity.
class="label">•: The number of SNpc DAergic neurons from m/m rats is 9% reduced.
class="label">•: Dopamine and glutamate release in the striatum from m/m rats is impaired.
class="label">•: Loss of striatal DAT- and VGluT1-expressing terminals occurs in m/m rats.