MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients

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MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients

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作者：Alessandro Arosio^a ; ^b ; ^{a.arosio10@campus.unimib.it" class="auth_mail" title="E-mail the corresponding author} ; Gessica Sala^a ; Virginia Rodriguez-Menendez^a ; Denise Grana^a ; ^b ; Francesca Gerardi^c ; Christian Lunetta^c ; Carlo Ferrarese^a ; ^d ; Lucio Tremolizzo^a ; ^d
关键词：Amyotrophic lateral sclerosis ; MEF2D ; MEF2C ; BDNF ; KLF6 ; RUFY3 ; NPEPPS ; HDAC4 ; HDAC5 ; SOD1
刊名：Molecular and Cellular Neuroscience
出版年：2016
出版时间：July 2016
年：2016
卷：74
期：Complete
页码：10-17
全文大小：893 K

文摘

class="label">•: MEF2D and MEF2C mRNA levels are up-regulated in both sporadic and SOD1 + ALS patients.
class="label">•: A different pattern of distribution for MEF2D and MEF2C in sALS cells was observed.
class="label">•: The MEF2 downstream targets BDNF, KLF6 and RUFY3 are decrease in both sALS and SOD1 + patients.

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