Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

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Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

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作者：Pei-Chi Wei¹ ; ² ; ³ ; ⁴ ; Amelia N. Chang¹ ; ² ; ³ ; ⁴ ; Jennifer Kao¹ ; ² ; ³ ; Zhou Du¹ ; ² ; ³ ; Robin M. Meyers¹ ; ² ; ³ ; Frederick W. Alt¹ ; ² ; ³ ; ^{alt@enders.tch.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Bjoern Schwer¹ ; ² ; ³ ; ^{bjoern.schwer@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell
出版年：2016
出版时间：11 February 2016
年：2016
卷：164
期：4
页码：644-655
全文大小：2372 K

文摘

class="label">•: 27 Recurrent DSB clusters (RDCs) are identified in neural stem/progenitor cells
class="label">•: All RDCs are within genes, most of which are long, transcribed, and late replicating
class="label">•: Most RDC genes are involved in synapse function and/or neural cell adhesion
class="label">•: A nucleotide-resolution view of replication stress-associated fragile sites is provided

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