Characterization and pharmacological analysis of two adipokinetic hormone receptor variants of the tsetse fly, Glossina morsitans morsitans

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Characterization and pharmacological analysis of two adipokinetic hormone receptor variants of the tsetse fly, Glossina morsitans morsitans

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作者：Jelle Caers^a ; ^{Jelle.Caers@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Tom Janssen^a ; ¹ ; ^{Tom.Janssen@cistim.be" class="auth_mail" title="E-mail the corresponding author} ; Liesbeth Van Rompay^a ; ^{Liesbeth.VanRompay@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Valé ; rie Broeckx^a ; ^{Valerie.Broeckx@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Jan Van Den Abbeele^b ; ^c ; ^{jvdabbeele@itg.be" class="auth_mail" title="E-mail the corresponding author} ; Gerd Gä ; de^d ; ^{gerd.gade@uct.ac.za" class="auth_mail" title="E-mail the corresponding author} ; Liliane Schoofs^a ; ^{Liliane.Schoofs@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Isabel Beets^a ; ^{Isabel.Beets@bio.kuleuven.be" class="auth_mail" title="E-mail the corresponding author}
关键词：Insect ; Tsetse fly ; Neuropeptide ; Adipokinetic hormone ; G protein-coupled receptor
刊名：Insect Biochemistry and Molecular Biology
出版年：2016
出版时间：March 2016
年：2016
卷：70
期：Complete
页码：73-84
全文大小：2506 K

文摘

class="label">•: cDNA cloning confirms two tsetse fly akhr splice variants and two AKH encoding genes.
class="label">•: Both Glomo-AKHRs are dose-dependently activated by two Glomo-AKH peptides in vitro.
class="label">•: Transcript profiles suggest conserved functions of AKH signaling in tsetse energy metabolism.
class="label">•: Structure–activity studies reveal pharmacological features of Glomo-AKH neuropeptides.

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